Formulation, Development, Evaluation and Solubility Enhancement of Lercanidipine Hydrochloride by Solid Dispersion Techniques

Background: Solid dispersions (SDs) are the dispersion of hydrophobic drugs in an inert hydrophilic carrier. SDs prepared to improve dissolution properties and bioavailability slightly water-soluble drug molecules by dispersing them into carrier.
 Aims Objective: Evaluate solubility Dispersion Lercanidipine Hydrochloride (LER).
 Materials Methods: To study effect polymer, studies were carried out. state characterizations solid performed differential scanning calorimetry (DSC).Drug- carrier interactions studied FT-IR spectroscopy, whereas X-ray diffraction powder was done demonstrate crystal structure dispersions.
 Results: The exhibited 94% release at 30 minutes which is higher than both LER pure MKT. Better characteristic confirmed 9.86 min MDT 63.12% DE30 that MKT (13.64 MDT, 46.92 % DE30) characterization revealed enhancement result conversion crystalline form less and/or amorphous form.
 Conclusion: can successfully be with PEG6000 ratio 1:6 using solvent evaporation technique. It a successful easy approach for increase onset action after administration facilitates treatment cardiovascular diseases.